Splenomegaly is an enlargement of the spleen beyond its normal size.

The spleen is an organ that is a part of the lymph system. It filters the blood and maintains healthy red and white blood cells and platelets.

Because of its wide variety of functions, the spleen may be affected by many conditions involving the blood or lymph system, and by infection, malignancies, liver disease, and parasites.

Symptoms of splenomegaly include:

• Inability to eat a large meal
• Pain on the upper left side of the abdomen
• Hiccups

• Infections
  • Bacterial infections
  • Cat scratch disease
  • Infectious mononucleosis (EBV or CMV)
  • Other viral infections
  • Parasitic infections
• Diseases involving the liver
  • Biliary atresia
  • Cirrhosis (alcoholic cirrhosis, portal vein obstruction, portal hypertension)
  • Cystic fibrosis
  • Sclerosing cholangitis
• Hemolytic anemias
  • Hemoglobinopathies
  • Hemolytic anemia due to G6PD deficiency
  • Idiopathic autoimmune hemolytic anemia
  • Immune hemolytic anemia
  • Thalassemia
• Cancer
  • Hodgkin's disease
  • Leukemia
  • Lymphoma
• Other causes
  • Felty syndrome
  • Sarcoidosis
  • Sickle cell splenic crisis

Appropriate limitation of activity, including avoiding contact sports, will help prevent trauma that might cause the spleen to rupture.

Care will be required for the specific condition causing the splenomegaly. Follow the instructions given by your health care provider regarding appropriate care.

Although often there are no symptoms from an enlarged spleen, you may experience pain in the left upper section of your abdomen. You should seek attention from your doctor right away if it is severe or gets worse when you take a deep breath.

The physician will ask a series of questions to determine if you have symptoms either from the enlarged spleen or the underlying cause of the large spleen, such as fever or signs of an infectious disease.

The doctor will also perform a thorough exam of your abdomen. To check for an enlarged spleen, he or she will percuss (tap) along the left upper quadrant of your abdomen and palpate (feel) in that same area, especially just under the rib cage.

Diagnostic tests may be required, including:

• Abdominal x-ray or CT scan
• Blood tests such as a CBC and tests of your liver function
• Tests for suspected causes

Armitage J. Approach to the patient with lymphadenopathy and splenomegaly. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 174.