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Felty syndrome

Contents of this page:

Illustrations

Antibodies
Antibodies

Definition    Return to top

Felty syndrome is a rare disorder that involves rheumatoid arthritis, a swollen spleen, decreased white blood cell count, and repeated infections.

Causes    Return to top

The cause of Felty syndrome is unknown. It is more common in people who have had rheumatoid arthritis for a long time. People with this syndrome are at risk of infection because they have a low white blood cell count.

Symptoms    Return to top

Exams and Tests    Return to top

A physical examination will show:

A complete blood count ( CBC) may show decreased number of white blood cells called neutrophils.

An abdominal ultrasound may confirm a swollen spleen.

Treatment    Return to top

Persons with this syndrome are usually already receiving treatment for rheumatoid arthritis. They may need other medicines to suppress their immune system.

Some people benefit from removal of the spleen (splenectomy).

Outlook (Prognosis)    Return to top

Rheumatoid arthritis is likely to get worse.

Possible Complications    Return to top

You may have infections that keep returning.

When to Contact a Medical Professional    Return to top

Call for an appointment with your health care provider if you develop symptoms of this disorder.

Prevention    Return to top

There is no known prevention.

References    Return to top

Pinals RS. Felty's syndrome. In: Firestein GS, Budd RC, Harris Jr. ED, McInnes IB, Ruddy S, eds. Kelley's Textbook of Rheumatology. 8th ed. Philadelphia, Pa: WB Saunders; 2008: chap 68.

Update Date: 5/31/2009

Updated by: Mark James Borigini, Associate Clinical Professor of Medicine, University of California, Irvine, Irvine, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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