1.2: Spontaneous Generation vs. Biogenesis
Read this page. The origin of life has always been fascinating, and the discovery of microbes was also followed by a debate on their origins. Prominent scientists of the time performed experiments to prove or disprove the spontaneous generation of microbes from non-living matter. The debate was going on for about 200 years, when finally Pasteur put off the spontaneous generation theory with a set of smartly designed and carefully performed experiments.
Read this page. Louis Pasteur was a meticulous experimenter, who believed that hard work should bring results. As Pasteur stated, "Chance favors only the prepared mind."
Read this review of Pasteur's experimental design for testing spontaneous generation. Pasteur's steps of observing, asking a question, making a hypothesis, conducting an experiment, and then accepting (or rejecting) his hypothesis later became codified as the scientific method.